CHAPTER 1 CAMPTOTHECIN AND ITS MECHANISM OF ACTION 1.1 History 1.2 Camptothecin: Mechanism of Action 1.3 Structure-Activity Relationships 1.4 The Homocamptothecin 1.5 The Future of Camptothecin References CHAPTER 2 WATER SOLUBLE DERIVATIVES OF CAMPTOTHECIN WITH POTENT ANTITUMOR ACTIVITY 2.1 Synthesis of Intermediate 2.2 Synthesis of Water Soluble Derivatives of Camptothecin 2.3 Cytotoxicity&